Summary: The SARS-CoV-2 papain-like protease (PLpro) is a target for antiviral drug development.It is essential for processing viral polyproteins for replication and functions in host immune evasion by cleaving ubiquitin (Ub) and ubiquitin-like protein (Ubl) conjugates.While highly conserved, SARS-CoV-2 and SARS-CoV PLpro have contrasting Ub/Ubl su
This study examines the role of Technology Anxiety (TA), age, past use, and cybersickness in the adoption of Virtual Reality (VR) technology.Using an extended Technology Acceptance Model (TAM), the research integrates age and past use as antecedents of TA and evaluates their influence on perceived ease of use (PEoU), Bocce perceived enjoyment (PENJ
This article tries to clearly analyze the way driven by the linguistic studies of language and discourse showing how much language has become an instrument of social inclusion and exclusion.Through this optic, in order to elucidate the route taken by language, the body of this work was built based on the 20th Century Linguistic study of Saussure, C
Religious hate propaganda, Play Gyms which is sustained communication by an authority that attempts to guide an audience towards persecuting others based on religion, is a speech crime.Yet, it is one of the least understood and most difficult speech crimes to prosecute.This is due to misunderstandings and epistemic gaps regarding how persecutory la
Objective The aim of this article is to describe the consensus process used to develop an acupuncture intervention protocol for an NIH-funded pragmatic randomized controlled trial (PRCT) of acupuncture for the management of chronic low back (cLBP) in older adults (BackInAction).Background CLBP is among leading causes of disability worldwide: almost